Formulation and Evaluation of Gas Powered Systems of Cefepime Tablets for Controlled Release

Abstract

The present work is aimed to formulate Cefepime floating tablets using different hydrophilic and hydrophobic polymers like hydroxypropylmethylcellulose (HPMC), Ethyl cellulose, Xanthum gum, guar gum, and gas generating agent Sodium bicarbonate. The develop gastroretentive dosage form that could retain the agent, namely, Cefepime in the stomach for longer periods of time delivering the drug to the site of action, that is, stomach. HPMC is used as a swelling agent, Guar gum and Xanthum gum are used as binding agent. Ethyl cellulose is used as matrix form agent. PVP is used as a suspending agent. Sodium bicarbonate is used as a gas forming agent. MCC is used as a disintergrant and diluent. Magnesium stearate is used as a lubricant. The prepared Cefepime tablets will be evaluated for drug content, entrapment efficiency, post-compression studies, in vitro buoyancy studies, swelling index studies, in vitro dissolution studies, release kinetics, and stability studies. All these parameters were found to be within the pharmacopoeial limits. Formulation F5 was selected for drug release and stability study on the basis of appropriate results of post-compression study. In vitro dissolution study was carried out and showed controlled release pattern.