Antifertility Effect of Aqueous Leaf Extract of Prosopis cineraria in Male Albino Rats

Abstract

Objective: The objective of the study was to evaluate the fertility effects of aqueous leaf extract of Prosopis cineraria treatment effects on fertility indices in male albino rats. Materials and Methods: The aqueous leaf extract was prepared according to conventional methods. The rats were randomly divided into three groups with six individuals in each group. Groups-I animals were used as control and given 0.5 ml distilled water by orally intubated. Group-II animals were administered 150 mg body weight of the aqueous extract for 35 days. Group-III animals were administered 250 mg/kg body weight of the aqueous extract for 35 days. Results: The aqueous leaf extract administered animals showed decrease in the weight of testis, epididymis, and seminal vesicles. In addition, sperm motility, sperm viability, and changes in testosterone levels were seen changes reproductive system, especially reduction of sperm count, motility and abnormal head and tail condition were also observed in the 250 mg/kg body weight extract administered of the animals, when compared to the control group. Conclusion: The aqueous leaf extract of P. cineraria showed antifertility effect in male albino rats. After the experimental period of 65 days without any oral administration of the plant extract, remarkable changes such as increase in the weight of the testis, epididymis, and seminal vesicle and also in the increment of the sperm count were found.