Evaluation Optimized Chewing Gum Formulations against Commercial Chlorpheniramine Maleate Tablet Formulation

Authors

  • Rehandle Trupti

DOI:

https://doi.org/10.22377/ijpscr.v1i3.44

Abstract

Oral route is most convenient for the patient, therefore, it is very popular in the society. Chewing gum delivery system is convenient, easy to administer anywhere, anytime and is pleasantly tasting, making it patient acceptable. It is a novel drug delivery system containing masticatory gum base with pharmacologically active ingredient and intended to use for local treatment of mouth diseases or systemic absorption through oral mucosa. Chewing gum is the convenient and effective means of rapidly administering chlorpheniramine maleate (CPM), as it is readily soluble, permeable, and used to relieve symptoms of allergy, hay fever, and common cold. In the present study, medicated chewing gum of CPM has been formulated using gum base, sorbitol, mannitol, magnesium stearate, lecithin, and menthol. This medicated chewing gum was prepared by direct compression method and formulated using various compositions of gum base and lecithin such as 30–35–40% and 5–10–15% accordingly. In the formulation, soya lecithin was used as a plasticizer and it was found that it acted on the drug release to some extent. When concentration of soya lecithin was increased, drug release was also found to be increased.

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Published

2021-09-15

How to Cite

Trupti, R. . (2021). Evaluation Optimized Chewing Gum Formulations against Commercial Chlorpheniramine Maleate Tablet Formulation. B R Nahata Smriti Sansthan International Journal of Phramaceutical Sciences & Clinical Research, 1(3). https://doi.org/10.22377/ijpscr.v1i3.44