Formulation and Evaluation Lumfantrine Nanoemulsion


  • Kuldeep Sen



The aim of the present study was to develop a self-nano emulsifying delivery system of lumefantrine (LF) to achieve rapid and complete dissolution independent of food-fat and surfactant in dissolution media. LF is a highly lipophilic fluorine derivative and a Biopharmaceutical Classification System CLASS II drug which is an important agent in the treatment of falciparum malaria. Poor oil solubility of LF has restricted the development of lipid-based system. In view of this inadequacy, the current study aims at improving the solubility of LF, especially to eliminate the co-administration of milk or any other fatty meal. Considering the basic nature of LF, we have planned to form LF-oleic acid ionic complex and to prepare self-emulsifying system of complex by addition of appropriate surfactant. Such a self-emulsifying hydrophobic complex enables rapid dissolution of LF, without the need of BKC in dissolution media, hence provide better correlation to in vivo condition.




How to Cite

Sen, K. . (2021). Formulation and Evaluation Lumfantrine Nanoemulsion. B R Nahata Smriti Sansthan International Journal of Phramaceutical Sciences & Clinical Research, 1(3).