Formulation and Evaluation of Gastroretentive Drug Delivery System of Repaglinide

Abstract

The concept of dosage form in which medicine is embedded, regardless of its safety and pharmacological effect, is developing successfully. Various scientific technologies have been developed for designing drug delivery systems.Floating microspheres were evaluated for micromeritics properties such as particle size, tapped and true density, and compressibility index and flow properties such as angle of repose. Repaglinide (Prandin) a member of meglitinide class used orally for secretion of insulin was selected for the present investigation. Various materials utilized during preformulation, formulation, characterization, and for other experimental work are given below. Laboratory/ analytical grade chemicals were used during the research work.The goal of the research work was to summarize the principals, mechanisms, and technological approaches of FDDS in general. Introduction part represented the physiological properties and factors influencing absorption and gastric motility in the stomach.