Cu(II) Metal Complexes of Pyridyl-based Schiff Bases and Their Biological Importance: A Review Study

Abstract

Schiff base plays a key role in the evolution of coordination chemistry as they form stable coordination compounds with most of the transition metal ions. Some important transition metals such as Co, Mn, Ni, Zn, and Cu have a significant role in the synthesis of the Schiff base metal complex. The synthesis of Schiff base transition metal Cu(II) complexes using Schiff base as ligands is studied keeping in view the possibility of obtaining coordination compounds of new structure with more stability. They also show excellent biological activities such as anti-inflammatory, analgesic, antibiotic, antioxidative, antifungal, antibacterial, antiviral, and enzymatic activities. The ligand and metal complexes are characterized by elemental analyses, molar conductivity, magnetic moment, FT-IR, UV-Vis, Mass, and ¹H-NMR spectrometry as well as thermal analyses. This review paper summarizes to know about the chemistry of different derivatives of substituted Schiff bases and their Cu(II) complexes with their biological importance.