Sodium Thiosulfate (Hydrogen Sulfide Donor): Ameliorates the Pituitary-testicular Axis Dysfunction Induced by Cyclophosphamide and/or Ionizing Gamma Radiation in Albino Rats

Authors

  • Ahmed H. Osman

Abstract

Background: Hypothalamic-pituitary-testicular axis represents a complex biological structure organ regulating reproductive function. The present study aimed to investigate the potential protective effect of sodium thiosulfate (STS) as a hydrogen sulfide donor on the pathophysiological effects of cyclophosphamide (CYP) and/or ionizing gamma radiation (IR) on pituitary-gonadal axis through the improvement of pathological, biochemical, and hormonal alteration in male rats. Materials and Methods: Rats of experimental groups were received STS (400 mg/kg b.w. for 14 days, i.p.) before treatment with CYP and/or IR, except normal control rats received saline only. 

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Published

2022-09-15

How to Cite

Osman, A. H. (2022). Sodium Thiosulfate (Hydrogen Sulfide Donor): Ameliorates the Pituitary-testicular Axis Dysfunction Induced by Cyclophosphamide and/or Ionizing Gamma Radiation in Albino Rats. B R Nahata Smriti Sansthan International Journal of Phramaceutical Sciences & Clinical Research, 2(3). Retrieved from http://ijpscr.info/index.php/ijpscr/article/view/107

Issue

Vol. 2 No. 3 (2022): International Journal of Pharmaceutical Sciences and Clinical Research

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.